Answers for some of the common questions asked by health care professionals.

1. How is SEASONIQUE™ different from traditional 28-day oral contraceptives?
   
   SEASONIQUE™ gives your patients more time between periods than the typical monthly Pill. With SEASONIQUE™, a woman takes pills for 3 months instead of 3 weeks. The final week of the pill pack contains low-dose estrogen instead of placebo. The patient should get her scheduled period during the last week of the pack.
   
   With SEASONIQUE™, patients are more likely to experience intermenstrual bleeding than with a 28-day oral contraceptive. This can be slight to a flow like a regular period and should decrease after the first 91-day cycle.
2. How is SEASONIQUE™ different from SEASONALE^®?
   
   SEASONIQUE™ has a unique extended regimen with continuous estrogen to eliminate the hormone-free interval. Its 91-day regimen contains 84 days of levonorgestrel/ethinyl estradiol tablets, 0.15 mg/0.03 mg, followed by 7 days of low-dose estrogen (ethinyl estradiol tablets, 0.01 mg) in place of placebo. Each prescription pack contains one full extended cycle (3-month supply).

   Click here for full SEASONALE^® US Prescribing Information.

3. What is the clinical tolerability and safety profile of SEASONIQUE™?
   
   In the pivotal clinical trial:
   • Side effects included: intermenstrual bleeding, menorrhagia, weight gain, and acne
   • Low incidence of nuisance side effects: headache, breast tenderness, and nausea reported by only 3% of women
   • Endometrial hyperplasia was not observed after completion of up to 1 year of treatment in a subset of 63 patients

   Serious as well as minor side effects have been reported with the use of hormonal contraceptives. Serious risks include blood clots, stroke, and heart attack. Cigarette smoking increases the risk of serious cardiovascular side effects, especially in women over 35 years.

   Please see important safety considerations in the full SEASONIQUE™ US Prescribing Information.

4. Since SEASONIQUE™ includes low-dose estrogen in place of placebo, will patients still get a period?
   
   Yes. Patients should get their scheduled period the last week of their pill pack. Some women using oral contraceptives, including SEASONIQUE™, may experience amenorrhea. If a patient misses a scheduled period while taking SEASONIQUE™, consider the possibility that she may be pregnant.